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Simultaneous inhibition of fungal cell wall and cell membrane biosynthesis could be hypothesized to result in a synergistic interaction between echinocandins and azoles against Aspergillus.

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Subtle chemical differences exist; however, the galactomannan of Aspergillus has striking structural similarity to that of Penicillium.

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This Danish team has been studying the safety of fluconazole in pregnancy for several years -- finding of congenital malformations associated with use of the drug in pregnant patients in 2013.

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Fluconazole is a drug that can be taken by mouth or given intravenously (IV) to treat invasive candidiasis.

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The drug then binds to DNA, and DNA breakage occurs.

However, the emergence of fluconazole-resistantCandida albicansisolates, increasingly serious drug resistance, narrow antifungal spectrum, and low activity against invasive mycoses have attracted great efforts towards modifying the side chain of Fluconazole or exploiting its new analogues.

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Q24h for 4 days) to 8 healthy male subjects resulted in an increase in C max and AUC of voriconazole by an average of 57% (90% CI: 20%, 107%) and 79% (90% CI: 40%, 128%), respectively.

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In addition, some studies suggest that resistance in Aspergillus may be partially driven by the use of agricultural azoles, which protect crops from fungi.

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