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Simultaneous inhibition of fungal cell wall and cell membrane biosynthesis could be hypothesized to result in a synergistic interaction between echinocandins and azoles against Aspergillus.
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Fluconazole may significantly increase cyclosporine levels in renal transplant patients with or without renal impairment.
Subtle chemical differences exist; however, the galactomannan of Aspergillus has striking structural similarity to that of Penicillium.
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This Danish team has been studying the safety of fluconazole in pregnancy for several years -- finding of congenital malformations associated with use of the drug in pregnant patients in 2013.
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The drug then binds to DNA, and DNA breakage occurs.
However, the emergence of fluconazole-resistantCandida albicansisolates, increasingly serious drug resistance, narrow antifungal spectrum, and low activity against invasive mycoses have attracted great efforts towards modifying the side chain of Fluconazole or exploiting its new analogues.
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Q24h for 4 days) to 8 healthy male subjects resulted in an increase in C max and AUC of voriconazole by an average of 57% (90% CI: 20%, 107%) and 79% (90% CI: 40%, 128%), respectively.
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In addition, some studies suggest that resistance in Aspergillus may be partially driven by the use of agricultural azoles, which protect crops from fungi.
In contrast, the calcineurin inhibitors CsA and FK506 cluster together on the vertical axis because they have highly similar chemical-genetic interaction profiles.
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There is little information on cross reactivity of hepatic injury between fluconazole and other antifungal azoles, such as ketoconazole, itraconazole, voriconazole and posaconazole, but a few reports suggest that there is little cross reactivity.
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Clinical utility of panfungal polymerase chain reaction for the diagnosis of invasive fungal disease: a single center experience.
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Concomitant oral administration of 100 mg fluconazole and 50 mg hydrochlorothiazide for 10 days in 13 normal volunteers resulted in a significant increase in fluconazole AUC and C max compared to fluconazole given alone.
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The effect of Fluconazole on the pharmacokinetics and pharmacodynamics of midazolam was examined in a randomized, cross-over study in 12 volunteers.
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Other 14-methyl sterols that were increased in organisms exposed to fluconazole were 14-methylfecosterol and eburicol.
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Less commonly, some patients fail to respond to therapy despite having a relatively "sensitive" organism isolated.
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Candida krusei should be considered to be resistant to fluconazole.
There are significant drug-drug interactions with azoles that need close review when using this class of antifungals.
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On the sixth day of dosing, fluconazole increased the midazolam AUC and Cmax by 259% and 74%, respectively.
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